Table 1.
Pharmacokinetic Parameters of ISL After Single I.V. Administration of ISL and ISL-M (2 Mg/Kg) to Rats
| Parameters | Unit | ISL | ISL-M |
|---|---|---|---|
| t1/2α | h | 0.07 ± 0.01 | 0.09 ± 0.01 |
| t1/2β | h | 0.70 ± 0.22 | 1.82 ± 0.35* |
| AUC (0-t) | ng/mL*h | 306.78 ± 92.53 | 459.05 ± 40.32* |
| AUC (0-∞) | ng/mL*h | 372.75 ± 105.57 | 555.25 ± 60.42* |
| MRT (0-t) | h | 0.17 ± 0.03 | 0.26 ± 0.03*** |
| CL | L/h/kg | 5.78 ± 1.74 | 3.64 ± 0.39* |
| Frel | % | 148.96 |
Notes: The results were expressed as the mean ± SD, n = 6; vs ISL group: *P < 0.05, ***P < 0.001.
Abbreviations: t1/2α, distribution half-life; t1/2β, elimination half-life; AUC, area under the plasma concentration–time curve; MRT, mean residence time; CL, clearance rate; Frel, relative bioavailability.