Table 2.
Targeting Tissue Evaluation of ISL-M
| Tissue | Cmax (ng/g) | Cp | AUC (ng*h/g) | Re | ||
|---|---|---|---|---|---|---|
| ISL | ISL-M | ISL | ISL-M | |||
| Heart | 69.15 ± 10.47 | 105.47 ± 39.84 | 1.53 | 18.66 ± 2.11 | 40.30 ± 7.31** | 2.16 |
| Liver | 574.44 ± 137.34 | 841.81 ± 64.01* | 1.47 | 207.70 ± 28.50 | 335.80 ± 37.09** | 1.62 |
| Lung | 178.70 ± 31.37 | 312.03 ± 63.38** | 1.75 | 55.24 ± 6.28 | 95.79 ± 12.80** | 1.73 |
| Kidney | 713.19 ± 35.02 | 1260.57 ± 313.03* | 1.77 | 174.7 ± 9.70 | 328.5 ± 52.98** | 1.88 |
| Brain | 21.69 ± 3.45 | 50.79 ± 14.08** | 2.34 | 8.34 ± 0.61 | 21.41 ± 2.46*** | 2.58 |
Notes: The results were expressed as the mean ± SD, n = 4; vs ISL group: *P < 0.05, **P < 0.01, ***P < 0.001.
Abbreviations: Cmax, maximum concentration; AUC, area under the concentration–time curve of different tissues; Cp, the ratio of peak concentration; Re, the relative rate of uptake.