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. 2022 Aug 8;13:920514. doi: 10.3389/fphar.2022.920514

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Copyright © 2022 Deng, Chen, Shi, Lin, Ou, Zhu, Wu, Li and Lv.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Free CUR and CUR-NPs suppress the migration and invasion of MDA-MB-231 cells. (A,B) A wound-healing assay was performed to investigate the migration of MDA-MB-231 cells after being treated with free CUR, CUR-NPs, or carrier. (C,D) The invasion abilities of MDA-MB-231 were studied by the transwell assay after cells were treated with free CUR, CUR-NPs, or carrier. NC, treated with negative control; carrier, treated with the carrier of PEG_5k-b-PLLA_5k; CUR, treated with free CUR; CUR-NPs, treated with CUR-loaded PEG_5k-b-PLLA_5k nanoparticles. **p < 0.01, ***p < 0.001.