TABLE 2.

The binding energies of CUR or co-crystallized ligands with related protein targets.

Name	PDB ID	Binding energy (kcal/mol)
		CUR	Co-crystallized ligands
STAT3	6NJS	−6.3	−9.1
AKT1	4EJN	−9.2	−13.9
TNF	6OOZ	−10.0	−12.5
PTGS2	5F1A	−8.8	−10.9
MMP9	4HMA	−8.2	−13.6
EGFR	1M17	−7.9	−7.4
PPARG	5UGM	−8.5	−10.6
NFE2L2 a	3ZGC	−7.8	—
EP300	5LKT	−9.7	−8.9
GSK3B	4J71	−7.4	−5.6

^aBecause the co-crystallized ligand of NFE2L2 in the database of RSCB PDB (https://www.rcsb.org/) is not a small molecular ligand, the co-crystallized ligand was not re-docked and scored.