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. 2022 Aug 8;13:947372. doi: 10.3389/fphar.2022.947372

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Copyright © 2022 Deng, Jiang, Zeng, Peng and Song.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Co-expression network and enrichment pathway analysis of PDHA1. (A) In total, 20 experimentally identified PDHA1-binding molecules were acquired by STRING. (B) Top six PDHA1-correlated genes analyzed by GEPIA2, including AIFM1, ATP5G3, COQ9, ESRRA, SUCLG1, and UQCRC1. (C) Heatmap representation of the expression correlation between PDHA1 and the top six PDHA1-correlated genes, AIFM1, ATP5G3, COQ9, ESRRA, SUCLG1, and UQCRC1, in 33 tumors. (D) Roles of PDHA1 in the metabolism signaling pathway by performing GSEA.