Table 3. Associations between Various Factors and Changes in Clinical Outcome Scores from Baseline to the 6 Months of Follow-up.
| Factor | n | ΔKOOS | ΔLysholm score | ΔVAS | ||||
|---|---|---|---|---|---|---|---|---|
| Mean ± SD | p-value | Mean ± SD | p-value | Mean ± SD | p-value | |||
| Age* (yr) | 0.934 | 0.401 | 0.795 | |||||
| ≤ 60 | 5 | 16.9 ± 8.2 | 18.6 ± 11.7 | –32.4 ± 28.8 | ||||
| > 60 | 6 | 16.4 ± 11.7 | 25.0 ± 12.4 | –36.3 ± 16.1 | ||||
| Sex | 0.908 | 0.508 | 0.017 | |||||
| Male | 6 | 16.3 ± 8.8 | 24.3 ± 14.2 | –21.2 ± 15.5 | ||||
| Female | 5 | 17.0 ± 11.9 | 19.4 ± 9.4 | –50.6 ± 16.6 | ||||
| BMI* (kg/m2) | 0.755 | 0.307 | 0.582 | |||||
| ≤ 27.5 | 5 | 17.7 ± 11.5 | 26.4 ± 12.7 | –38.6 ± 16.9 | ||||
| > 27.5 | 6 | 15.7 ± 9.1 | 18.5 ± 11.1 | –31.2 ± 25.9 | ||||
| Number of ADRCs* | 0.986 | 0.947 | 0.057 | |||||
| ≤ 1.0 × 107 | 5 | 16.7 ± 9.8 | 21.8 ± 14.2 | –21.4 ± 17.3 | ||||
| > 1.0 × 107 | 6 | 16.6 ± 10.7 | 22.3 ± 11.1 | –45.5 ± 19.4 | ||||
The unpaired t-test was performed to determine statistical significance.
Δ: the amount of change from preoperative to 6 months postoperative, KOOS: Knee Injury and Osteoarthritis Outcome Score, VAS: visual analog scale, SD: standard deviation, BMI: body mass index, ADRC: adipose-derived regenerative cell.
*Median values are used as standard values for dividing the groups.