Table 2.
Baseline characteristics of discovery phase participants.
| Variable |
Controls (n = 86) |
Sus-AF (n = 30) |
All-AFs plus Car-AF (n = 113) |
P | |
|---|---|---|---|---|---|
| Demographics | Male | 38 (43.7) | 14 (46.7) | 73 (64.6) | – |
| Age | 57.47 ± 6.58 | 54.83 ± 9.57 | 65.59 ± 11.66 | * | |
| Weight | 61.66 ± 8.62 | 65.68 ± 9.13 | 69.99 ± 11.91 | * | |
| Height | 1.65 ± 0.08 | 1.67 ± 0.08 | 1.68 ± 0.08 | * | |
| BMI | 22.62 ± 1.77 | 23.62 ± 2.36 | 24.70 ± 3.31 | * | |
| BSA | 1.76 ± 0.15 | 1.82 ± 0.15 | 1.88 ± 0.18 | * | |
| SBP | 121.01 ± 10.79 | 128.6 ± 16.36 | 136.91 ± 20.33 | * | |
| DBP | 74.15 ± 7.92 | 81.73 ± 11.74 | 82.59 ± 12.49 | #* | |
| Crcl | 91.92 ± 15.33 | 106.74 ± 31.19 | 86.96 ± 36.92 | – | |
| HbAlc | 5.6 (5.3, 5.9) | 5.6 (5.4, 5.8) | 5.9 (5.5, 6.3) | * | |
| Liver function | ALT | 14.8 (11.5, 19.4) | 19.9 (14.0, 26.0) | 16 (13, 22.6) | # |
| AST | 17.8 (15.9, 20.7) | 21.35 (17.7, 23.3) | 19.1 (15.1, 22.3) | # | |
| ALP | 57.1 (48.2, 70.9) | 67.45 (56.3, 78.8) | 68.9 (58.0, 83.4) | * | |
| γ-GT | 18.0 (14.9, 25.8) | 25.5 (18.7, 55.3) | 25.0 (18.1, 46.8) | #* | |
| LDH | 180 (162, 201) | 182 (155, 216) | 188 (166, 224) | – | |
| TBiL | 11.50 ± 4.73 | 11.93 ± 3.68 | 13.29 ± 6.91 | – | |
| TP | 70.42 ± 3.71 | 65.52 ± 4.78 | 65.33 ± 5.07 | #* | |
| Alb | 43.74 ± 1.45 | 40.65 ± 2.10 | 39.84 ± 2.93 | #* | |
| Glo | 26.68 ± 3.27 | 24.87 ± 3.89 | 25.49 ± 3.86 | – | |
| AG-ratio | 1.66 ± 0.21 | 1.67 ± 0.26 | 1.60 ± 0.25 | – | |
| Kidney function | GLU | 5.18 (4.81, 5.46) | 4.75 (4.51, 5.06) | 4.96 (4.56, 5.66) | # |
| BUN | 5.17 ± 1.05 | 4.97 ± 1.46 | 5.84 ± 1.75 | * | |
| CREA | 62.75 ± 11.08 | 61.70 ± 12.65 | 68.63 ± 18.67 | * | |
| URIC | 319.53 ± 59.61 | 344.10 ± 87.23 | 359.31 ± 101.75 | * | |
| T-CO2 | 25.60 ± 1.53 | 24.89 ± 1.25 | 25.26 ± 2.22 | – | |
| eGFR | 105.67 ± 16.55 | 111.97 ± 23.83 | 102.95 ± 24.17 | – | |
| Blood lipids | TG | 0.94 (0.74, 1.33) | 1.29 (1.05, 1.61) | 1.14 (0.87, 1.63) | #* |
| CHOL | 4.89 ± 0.75 | 4.32 ± 0.91 | 4.31 ± 0.84 | #* | |
| HDL | 1.57 ± 0.39 | 1.22 ± 0.44 | 1.21 ± 0.36 | #* | |
| LDL | 2.76 ± 0.61 | 2.45 ± 0.71 | 2.47 ± 0.73 | * | |
| White blood | WBC | 5.59 ± 1.27 | 5.65 ± 1.66 | 6.60 ± 2.43 | * |
| cells items | NEUT% | 57.84 ± 8.10 | 60.24 ± 9.36 | 62.97 ± 12.40 | * |
| LYMPH% | 33.71 ± 7.41 | 30.76 ± 8.68 | 27.54 ± 10.78 | * | |
| MONO% | 5.71 ± 1.36 | 6.34 ± 1.48 | 6.90 ± 2.17 | * | |
| EOS% | 2.24 ± 1.36 | 2.24 ± 1.50 | 2.13 ± 2.00 | – | |
| BASO% | 0.50 ± 0.26 | 0.42 ± 0.19 | 0.45 ± 0.30 | – | |
| NEUT# | 3.26 ± 0.98 | 3.45 ± 1.30 | 4.36 ± 2.39 | * | |
| LYMPH# | 1.87 ± 0.52 | 1.67 ± 0.54 | 1.65 ± 0.66 | * | |
| MONO# | 0.32 ± 0.12 | 0.36 ± 0.15 | 0.45 ± 0.20 | * | |
| EOS# | 0.11 (0.06, 0.16) | 0.11 (0.05, 0.20) | 0.10 (0.05, 0.16) | – | |
| BASO# | 0.03 ± 0.01 | 0.02 ± 0.01 | 0.03 ± 0.02 | – | |
| Red blood | RBC | 4.62 ± 0.38 | 4.35 ± 0.40 | 4.49 ± 0.57 | # |
| cells items | HGB | 142.15 ± 11.94 | 134.43 ± 14.65 | 141.73 ± 17.25 | – |
| HCT | 42.54 ± 3.29 | 39.11 ± 3.48 | 41.34 ± 4.82 | – | |
| MCV | 92.26 ± 4.88 | 90.08 ± 4.31 | 92.24 ± 4.95 | – | |
| MCH | 30.83 ± 1.82 | 30.92 ± 1.94 | 31.63 ± 1.92 | * | |
| MCHC | 334.07 ± 6.35 | 343.23 ± 10.62 | 342.84 ± 10.96 | #* | |
| RDW | 12.8 (12.5, 13.2) | 12.8 (12.3, 13.2) | 12.6 (12.2, 13.1) | – | |
| Platelets | PLT | 203.40 ± 46.01 | 208.47 ± 69.77 | 180.82 ± 59.02 | * |
| items | PCT | 0.21 ± 0.04 | 0.21 ± 0.06 | 0.20 ± 0.05 | – |
| PDW | 16.3 (16.0, 16.4) | 16.2 (15.7, 16.6) | 16.2 (16.0, 16.4) | – | |
| MPV | 10.20 ± 1.25 | 10.75 ± 1.83 | 10.96 ± 1.40 | * |
# and * indicate significant differences in groups Sus-AF and All-AFs plus Car-AF compared with the Control, respectively. BMI, body mass index; BSA, body surface area; SBP, systolic blood pressure; DBP, diastolic blood pressure; Crcl, creatinine clearance; HbAlc, glycated hemoglobin; ALT, alanine aminotransferase; AST, aspartate aminotransferase; ALP, alkaline phosphatase; γ-GT, γ-glutamyltransferase; LDH, lactate dehydrogenase; TBiL, total bilirubin; TP, total protein; Alb, albumin; Glo, globulin; AG-ratio, the ratio of albumin to globulin; GLU, glucose; BUN, blood urea nitrogen; CREA, Creatinine; UA, uric acid; T-CO2, total carbon dioxide; eGFR, endogenous glomerular filtration rate; TG, triglyceride; CHOL, total cholesterol; HDL, high density lipoprotein; LDL, low density lipoprotein; WBC, number of white blood cells; NEUT%, percentage of neutrophils; LYMPH%, percentage of lymphocytes; MONO%, percentage of monocytes; EOS%, percentage of eosinophils; BASO%, percentage of basophils; NEUT#, number of neutrophils; LYMPH#, number of lymphocytes; MONO#, number of monocytes; EOS#, number of eosinophils; BASO#, number of basophils; RBC, number of red blood cells; HGB, hemoglobin content; HCT, hematocrit; MCV, mean red blood cell volume; MCH, mean red blood cell hemoglobin content; MCHC, mean red blood cell hemoglobin concentration; RDW, red blood cell distribution width; PLT, number of platelet; PCT, platelet hematocrit; PDW, platelet distribution width; MPV, mean platelet cell volume.