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. 2022 Aug 8;16:902278. doi: 10.3389/fncel.2022.902278

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Copyright © 2022 Duncan, Riordan, Hall, Payne, Chapman and Koulen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression of cannabinoid receptor type 2 (CB2) in ReN cells under conditions of oxidative stress. (A) Images show that tert-butylhydroperoxide (tBHP) has no apparent effect on CB2 IR (green). Blue are DAPI-labeled nuclei. Images are 400× magnification. (B) Quantitative analysis of images in panel (A) reveals that tBHP has no significant effect on CB2 IR, although a trend toward an increase exists (0.10 < p < 0.05). (C,D) Western blot analysis reveals that the expression of a 48 kDa band (expected molecular weight of glycosylated CB2 is 46 kDa) corresponding to CB2 is downregulated by 40% by exposure to 2 μM tBHP and upregulated 45% by exposure to 10 μM tBHP. *p ≤ 0.05.