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. 2022 Aug 8;13:892460. doi: 10.3389/fphar.2022.892460

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Copyright © 2022 Mustafa, Jalil, Zainalabidin, Saleh, Asmadi and Kamisah.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic representation of mechanisms of sacubitril/valsartan on renin-angiotensin-aldosterone system and natriuretic peptide system. ACE, angiotensin converting enzyme; Ang, angiotensin; ANP, atrial natriuretic peptide; ARB, angiotensin receptor blocker; ARNI, angiotensin receptor-neprilysin inhibitor; AT₁R, angiotensin type 1 receptor; BNP, B-type natriuretic peptide; CNP, C-type natriuretic peptide; HFrEF, heart failure with reduced ejection fraction; NP natriuretic peptide; RAAS, renin-angiotensin-aldosterone system; ↑, increase.