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. 2022 Aug 8;13:881722. doi: 10.3389/fimmu.2022.881722

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Copyright © 2022 Chen, He, Chen, Wang, Dai, Liang, Wu, Luo, Zhang, Peng, Zhang, Liu, Zhang, Zhang and Cheng

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PDIA5 regulates the expression of PD-L1 and SPP1 in U251 cells and promotes the proliferation and clone formation of hepG2, U251, and PC3 cells. (A) The transduction results of different PDIA5 siRNA are verified using western blotting. (B) The protein expression level of PDIA5 in hepG2, U251, and PC3 cells after transfection with siRNA-PDIA5-1 and siRNA-PDIA5-2. (C) The protein expression level of PD-L1 and SPP1 in U251 cells after transfection with siRNA-PDIA5-1 and siRNA-PDIA5-2. (D) The cell proliferation of hepG2, U251, and PC3 cells after transfection of siRNA-PDIA5-1 and siRNA-PDIA5-2. (E) The clone formation of hepG2, U251, and PC3 cells after transfection of siRNA-PDIA5-1 and siRNA-PDIA5-2. Data are displayed as mean ± SD based on three independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001, and ****p< 0.0001 compared with the normal control (NC) group. ns, no significance.