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. 2022 Aug 8;13:881722. doi: 10.3389/fimmu.2022.881722

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Copyright © 2022 Chen, He, Chen, Wang, Dai, Liang, Wu, Luo, Zhang, Peng, Zhang, Liu, Zhang, Zhang and Cheng

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PDIA5 mediates the invasion of tumor cells and the migration of M2 macrophages. (A, B) The invasion of hepG2, U251, and PC3 cells after transfection of siRNA-PDIA5-1 and siRNA-PDIA5-2. (C) The induction process and morphology of M2 macrophages. (D) The schematic diagram illustrates the coculture of M2 macrophages and hepG2, U251, or PC3 cells. (E, F) The migration of M2 macrophages after being cocultured with hepG2, U251, and PC3 cells transfected with siRNA-PDIA5-1 and siRNA-PDIA5-2. Data are displayed as mean ± SD based on three independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001 compared with the normal control (NC) group.