Table 1.
The association between miRNAs levels and markers of myocardial injury in patients with Chronic Chagas Cardiomyopathy (n=74).
| Parameter | Models | let-7d-5p* (n=45) | miR-185-5p* (n=50) | miR-208a-5p* (n=32) | miR-223-5p* (n=50) | miR-34a-5p* (n=48) | miR-454-5p* (n=41) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| β (95% CI) | p-value | β (95% CI) | p-value | β (95% CI) | p-value | β (95% CI) | p-value | β (95% CI) | p-value | β (95% CI) | p-value | ||
| NT-proBNP (pg/ml) | Model 1 | -527.08 (-3923.70; 2869.54) | 0.756 | 744. 69 (-1924.35; 3413.73) | 0.577 | -6783.36 (-19422.10; 5855.38) | 0.278 | -522 (-3626.81; 2582.49) | 0.736 | 765.33 (-4130.48; 5661.14) | 0.754 | -13419.77 (-79328.32; 52488.77) | 0.682 |
| Model 2 | 983.34 (-2276.32; 4242.99) | 0.545 | -88.12 (-2549.95; 2373.70) | 0.943 | -2894.65 (-8194.43; 2405.13) | 0.268 | -48.72 (-3086.83; 2989.38) | 0.974 | -743.99 (-4747.21; 3258.22) | 0.709 | -4046.96 (-67333.6; 59239.7) | 0.897 | |
| LVEF (%) | Model 1 | 2.20 (-1.48; 5.88) | 0.234 | -0.15 (-4.52; 4.21) | 0.944 | 10.39 (-5.10; 25.88) | 0.179 | 3.03 (-1.08; 7.13) | 0.144 | 0.11 (-5.27; 5.48) | 0.969 | -2.41 (-6.11; 1.28) | 0.194 |
| Model 2 | 1.30 (-2.72; 5.32) | 0.516 | -0.46 (-4.93; 4.01) | 0.835 | 13.18 (-3.16; 29.53) | 0.108 | 3.58 (-0.39; 7.55) | 0.076 | -0.71 (-6.41; 4.99) | 0.802 | -79.97 (-183.19; 23.24) | 0.124 | |
| GLS (%) | Model 1 | -1.06 (-2.55; 0.43) | 0.158 | -0.22 (-2.15; 1.71) | 0.821 | -1.83 (-7.69; 4.03) | 0.522 | -1.08 (-2.82; 0.66) | 0.219 | -0.19 (-2.37; 1.98) | 0.860 | 2.31 (-42.75; 47.38) | 0.917 |
| Model 2 | -0.86 (-2.49; 0.78) | 0.296 | 0.01 (-1.91; 1.93) | 0.993 | -2.93 (-9.16; 3.29) | 0.337 | -1.34 (-3.06; 0.39) | 0.126 | 0.61 (-1.61; 2.83) | 0.579 | 10.14 (-34.28; 54.56) | 0.644 | |
| LA Area (cm2) | Model 1 | 0.36 (-5.69; 6.41) | 0.903 | -1.52 (-11.59; 8.64) | 0.758 | -37.97 (-82.92; 6.98) | 0.089 | -8.42 (-15.32; -1.52) | 0.019 | 1.88 (-6.56; 10.33) | 0.649 | 200.36 (66.36; 334.35) | 0.005 |
| Model 2 | -3.74 (-9.87; 2.39) | 0.218 | -2.56 (-12.82; 7.68) | 0.609 | -24.89 (-89.17; 39.38) | 0.398 | -10.21 (-16.35; -4.09) | 0.002 | -0.65 (-10.19; 8.90) | 0.889 | 168.33 (4.35; 332.29) | 0.045 | |
| ESV-LV (ml) | Model 1 | -12.85 (-39.03; 13.33) | 0.322 | -25.62 (-73.86; 22.62) | 0.284 | -110.38 (-246.81; 26.04) | 0.102 | -45.40 (-73.78; -17.03) | 0.003 | 1.24 (-39.55; 42.02) | 0.950 | 466.35 (-418.15; 1350.86) | 0.284 |
| Model 2 | -11.65 (-42.94; 19.65) | 0.448 | -23.65 (-76.31; 29.01) | 0.361 | -161.91 (-352.21; 28.39) | 0.085 | -45.34 (-74.06; -16.61) | 0.004 | 3.29 (-45.76; 52.36) | 0.889 | 726 (-462.64; 1914.68) | 0.214 | |
| EDV-LV (ml) | Model 1 | -11.26 (-41.19; 18.68) | 0.446 | -23.68 (-77.78; 30.43) | 0.376 | -137.89 (-275.21; -0.57) | 0.049 | -44.86 (-80.19; -9.53) | 0.015 | 4.32 (-39.37; 48.00) | 0.840 | 619.26 (-375.59; 1614.12) | 0.209 |
| Model 2 | -9.50 (-44.59; 25.58) | 0.579 | -19.72 (-77.53; 38.10) | 0.486 | -187.01 (-380.47; 6.46) | 0.056 | -46.13 (-81.99; -10,26) | 0.014 | 5.54 (-46.45; 57.53) | 0.825 | 900.61 (-440.06; 2241.28) | 0.174 | |
| LV mass index (g/m2) | Model 1 | 9.99 (-14.29; 34.26) | 0.411 | 11.22 (-14.65; 37.09) | 0.387 | -74.39 (-171.38; 22.61) | 0.126 | -1.22 (-29.24; 26.79) | 0.930 | 26.06 (-7.14; 59.26) | 0.121 | -23.01 (-631.90; 585.89) | 0.939 |
| Model 2 | 13.72 (-13.06; 40.49) | 0.306 | 7.99 (-19.71; 35.71) | 0.563 | -68.88 (-180.82; 43.05) | 0.214 | 1.70 (-28.35; 31.75) | 0.909 | 20.61 (-16.62; 57.82) | 0.270 | -9.16 (-672.68; 654.25) | 0.978 | |
| TAPSE (mm) | Model 1 | -1.24 (-3.59; 1.11) | 0.293 | -0.19 (-2.44; 2.40) | 0.987 | -8.33 (-16.59; -0.06) | 0.048 | 1.23 (-1.36; 3.83) | 0.345 | -0.49 (-3.59; 2.61) | 0.751 | 28.85 (-33.12; 90.81) | 0.352 |
| Model 2 | -1.43 (-3.91; 1.05) | 0.251 | 0.38 (-2.09; 2.86) | 0.757 | -8.01 (-17.18; 1.17) | 0.084 | 0.59 (-2.09; 3.28) | 0.659 | -1.49 (-4.80; 1.81) | 0.365 | 34.15 (-32.08; 100.39) | 0.302 | |
| Mitral flow E velocity (cm/s) | Model 1 | -3.44 (-17.02; 10.14) | 0.611 | 1.03 (-14.76; 16.82) | 0.896 | 22.98 (-36.61; 82.56) | 0.433 | 4.86 (-14.21; 23.94) | 0.610 | 1.38 (-16.97; 19.74) | 0.880 | 343.99 (-42.87; 730.86) | 0.080 |
| Model 2 | -6.97 (-21.49;7.55) | 0.337 | 0.91 (-14.88; 16.71) | 0.907 | 15.09 (-45.11; 75.29) | 0.607 | 4.11 (-15.72; 23.93) | 0.678 | 6.74 (-13.01; 26.49) | 0.493 | 347.25 (-92.14; 786.63) | 0.117 | |
| E/e’ lateral ratio | Model 1 | 0.03 (-2.19; 2.25) | 0.980 | -0.02 (-2.87; 2.82) | 0.986 | -4.22 (-14.20; 5.76) | 0.387 | 0.77 (-2.37; 3.91) | 0.622 | -0.09 (-3.01; 2.82) | 0.950 | 9.87 (-41.77; 61.50) | 0.699 |
| Model 2 | -0.32 (-2.87; 2.22) | 0.796 | -0.39 (-3.12; 2.34) | 0.773 | -2.93 (-12.57; 6.70) | 0.530 | 0.50 (-2.77; 3.77) | 0.757 | 0.34 (-2.73; 3.41) | 0.823 | 2.64 (-57.42; 62.69) | 0.929 | |
*Natural log-transformed values.
Bold text represent p-values < 0.05.
Model 1: Model adjusted by age and sex.
Model 2: Model adjusted by sex, age, BMI, and HF medications.