Table 3.

Reactome pathway analysis of target genes for hsa- miR-223-5p.

Pathway name	Entities found	Entities total	Entities ratio	p-value	Adjusted p-value
Negative regulation of the PI3K/AKT network	12	137	0.009	0.0000132	0.00396
Signaling by Receptor Tyrosine Kinases	28	620	0.041	0.0000177	0.00396
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	11	129	0.009	0.0000385	0.00675
SHC-mediated cascade:FGFR2	6	33	0.002	0.0000425	0.00675
FRS-mediated FGFR2 signaling	6	34	0.002	0.00005	0.00683
Extra-nuclear estrogen signaling	10	111	0.007	0.000055	0.00683
Insulin receptor signalling cascade	8	72	0.005	0.0000741	0.00823
Downstream signaling of activated FGFR2	6	42	0.003	0.000157	0.0135
IRS-mediated signalling	7	65	0.004	0.000251	0.0173
Laminin interactions	5	31	0.002	0.000322	0.0208
Negative regulation of MAPK pathway	6	49	0.003	0.000355	0.0208
IRS-related events triggered by IGF1R	7	69	0.005	0.000359	0.0208
IGF1R signaling cascade	7	72	0.005	0.000461	0.0254
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	7	73	0.005	0.0005	0.0265
Signaling by Insulin receptor	8	97	0.006	0.000541	0.0271
Atorvastatin ADME	4	20	0.001	0.000586	0.0278
SHC1 events in ERBB2 signaling	5	36	0.002	0.000632	0.0278
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	4	21	0.001	0.000702	0.0302