TABLE 1.
Top 10 terms with the largest significant differences in the GO biological process analysis of the mRNAs co-expressed with circRNAs.
| ID | Term | Count | GeneRatio | BgRatio | Pvalue | Candidate gene |
|---|---|---|---|---|---|---|
| GO:0030198 | extracellular matrix organization | 70 | 70/717 | 302/23328 | 3.99E-41 | Col9a2/Col11a1/Comp/Col8a2/Col13a1/Col22a1/Abi3bp/Col5a3/Myo1e/Tgfbr1/Itgb3/Adamts1/Cyp1b1/Eln/Col27a1/Loxl3/Mmp14/Col1a1/Sulf1/Aebp1/Col14a1/Col5a2/Col5a1/Postn/Col1a2/Loxl1/Scx/Adamts2/Olfml2b/Col16a1/Sh3pxd2b/Mfap4/Col8a1/Tgfb1/Ccn2/Slc2a10/Ccn1/Col15a1/Col4a1/Col4a2/Crispld2/Tgfb2/Foxc2/Bcl3/Tnfrsf11b/Fscn1/Col18a1/Lox/Fn1/Adamts16/Sfrp2/Angptl7/Mmp2/Antxr1/Nid1/Tnfrsf1b/Lum/Wt1/Adamts9/Lamb3/Kif9/Lgals3/Adtrp/Col4a4/Papln/Acan/Npnt/Sox9/Adamts19/Col4a3 |
| GO:0043062 | extracellular structure organization | 70 | 70/717 | 303/23328 | 5.04E-41 | Col9a2/Col11a1/Comp/Col8a2/Col13a1/Col22a1/Abi3bp/Col5a3/Myo1e/Tgfbr1/Itgb3/Adamts1/Cyp1b1/Eln/Col27a1/Loxl3/Mmp14/Col1a1/Sulf1/Aebp1/Col14a1/Col5a2/Col5a1/Postn/Col1a2/Loxl1/Scx/Adamts2/Olfml2b/Col16a1/Sh3pxd2b/Mfap4/Col8a1/Tgfb1/Ccn2/Slc2a10/Ccn1/Col15a1/Col4a1/Col4a2/Crispld2/Tgfb2/Foxc2/Bcl3/Tnfrsf11b/Fscn1/Col18a1/Lox/Fn1/Adamts16/Sfrp2/Angptl7/Mmp2/Antxr1/Nid1/Tnfrsf1b/Lum/Wt1/Adamts9/Lamb3/Kif9/Lgals3/Adtrp/Col4a4/Papln/Acan/Npnt/Sox9/Adamts19/Col4a3 |
| GO:0001503 | ossification | 53 | 53/717 | 394/23328 | 1.34E-19 | Dhh/Twist2/Atp6v0a4/Mdk/Shox2/Comp/Col13a1/Ptn/Hoxa2/Stc1/Igfbp3/Fbn2/Egr2/Pthlh/Mmp14/Col1a1/Runx1/Col1a2/Scx/Igsf10/Enpp1/Runx2/Sh3pxd2b/Sgms2/Tmem119/Bcl2/Tgfb1/Ccn2/Ccn1/Cd276/Foxc2/Ccn4/Lox/Cthrc1/Fgf23/Rflnb/Aspn/Sfrp2/Thbs3/Mgp/Sfrp1/Mmp2/Omd/Junb/Cebpd/Cnmd/Npnt/H3f3b/Sox9/Clec11a/Acp5/Clic1/Bmp7 |
| GO:0030199 | collagen fibril organization | 21 | 21/717 | 56/23328 | 6.39E-18 | Col11a1/Comp/Col13a1/Tgfbr1/Cyp1b1/Loxl3/Col1a1/Aebp1/Col14a1/Col5a2/Col5a1/Col1a2/Loxl1/Scx/Adamts2/Tgfb2/Foxc2/Lox/Sfrp2/Lum/Acan |
| GO:0061448 | connective tissue development | 42 | 42/717 | 276/23328 | 9.55E-18 | Prrx2/Mdk/Shox2/Col11a1/Comp/Tgfbr1/Stc1/Itgb3/Arid5a/Creb3l2/Thbs1/Col27a1/Pthlh/Col1a1/Sulf1/Runx1/Col5a1/Frzb/Scx/Runx2/Sh3pxd2b/Tgfb1/Ccn2/Ccn1/Chst11/Tgfb2/Foxc2/Ccn4/Lox/Rflnb/Sfrp2/Thbs3/Ctsk/Mgp/Matn3/Wt1/Efemp1/Cnmd/Acan/Sox9/Egr1/Bmp7 |
| GO:0051216 | cartilage development | 35 | 35/717 | 200/23328 | 6.14E-17 | Prrx2/Mdk/Shox2/Col11a1/Comp/Tgfbr1/Stc1/Arid5a/Creb3l2/Thbs1/Col27a1/Pthlh/Col1a1/Sulf1/Runx1/Frzb/Scx/Runx2/Tgfb1/Ccn2/Ccn1/Chst11/Tgfb2/Ccn4/Rflnb/Sfrp2/Thbs3/Ctsk/Mgp/Matn3/Efemp1/Cnmd/Acan/Sox9/Bmp7 |
| GO:0048705 | skeletal system morphogenesis | 36 | 36/717 | 253/23328 | 1.82E-14 | Twist2/Prrx2/Wnt9b/Shox2/Col11a1/Comp/Mdfi/Col13a1/Hoxa2/Tgfbr1/Stc1/Fbn2/Thbs1/Col27a1/Pthlh/Frem1/Mmp14/Col1a1/Tgfb3/Scx/Runx2/Sh3pxd2b/Tmem119/Ccn2/Chst11/Tgfb2/Foxc2/Rflnb/Sfrp2/Thbs3/Sfrp1/Mmp2/Acan/Sox9/Acp5/Bmp7 |
| GO:1901342 | regulation of vasculature development | 43 | 43/717 | 356/23328 | 1.97E-14 | Mdk/Tnmd/Ptn/Plk2/Itgb3/Adamts1/Cyp1b1/Thbs1/Chil1/Serpinf1/Sulf1/Ptgis/Runx1/Ddah1/Sparc/Tnfrsf12a/Col4a2/Tgfb2/Foxc2/Cd40/Ccl11/Sfrp2/Angptl7/Ism1/Ccl5/Cd34/Cxcr4/Wt1/Adamts9/Sphk1/Kit/Aplnr/Cnmd/Enpp2/Lgals3/Vash1/Tbxa2r/Cysltr2/Egr1/Adgra2/Col4a3/Bmp7/Cth |
| GO:0002062 | chondrocyte differentiation | 22 | 22/717 | 109/23328 | 1.92E-12 | Mdk/Shox2/Col11a1/Comp/Tgfbr1/Arid5a/Creb3l2/Col27a1/Pthlh/Sulf1/Runx1/Scx/Runx2/Tgfb1/Ccn2/Chst11/Ccn4/Rflnb/Sfrp2/Efemp1/Acan/Sox9 |
| GO:0045765 | regulation of angiogenesis | 37 | 37/717 | 320/23328 | 2.37E-09 | Mdk/Tnmd/Ptn/Plk2/Itgb3/Adamts1/Cyp1b1/Thbs1/Chil1/Serpinf1/Sulf1/Ptgis/Runx1/Ddah1/Sparc/Tnfrsf12a/Col4a2/Tgfb2/Foxc2/Cd40/Ccl11/Sfrp2/Ism1/Ccl5/Cd34/Cxcr4/Adamts9/Sphk1/Aplnr/Cnmd/Enpp2/Lgals3/Vash1/Tbxa2r/Cysltr2/Adgra2/Col4a3 |