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. 2022 Aug 8;12:981009. doi: 10.3389/fonc.2022.981009

Figure 1.

Figure 1

Expression and localization of integrin α11 in human cutaneous lesions. (A) Representative images of integrin α11 expression and localization in human skin lesions, stained with a monoclonal anti-human integrin α11 antibody (clone 210F4B6A4) (26). Integrin α11 showed strong expression around sweat glands in the tumor-adjacent normal skin, likely in the myoepithelial cells of the acini (arrowheads); scant positive signals in spindle-shaped cells at the dermal-epidermal junction (arrowheads) in benign seborrheic keratosis, premalignant actinic keratosis, and in squamous carcinoma in situ; generally moderate or strong signals in spindle-shaped cells distributed within the fibrillar stroma; and present in a tangle-like pattern at the tumor−stroma interphase (arrowheads) in malignant keratoacanthoma and cutaneous squamous cells carcinomas (cSCC). Stromal α11 staining is strong in grade 3 cSCCs. (B) A boxplot diagram representing the staining index score in seborrhoeic keratosis (SK), actinic keratosis (AK), in situ carcinomas (in situ), keratoacanthomas (KA), and cSCCs. Arrowheads, α11 signals. A, adipocyte, BV, blood vessel; D, dermis; E, epidermis; K, keratin; M, muscle; S, stroma; T, tumor. Scale bars, 100 μm. ***, p<0.001.