Figure 2.

CFA treatment results in reduced mechanical thresholds and increase corticosterone levels in the absence of motor impairment. (a, b): Mechanical thresholds (g) in the von Frey test for the ipsilateral (a) and contralateral (b) hindpaws at baseline (BL) and at 3, 7, and 10 days following the intraplantar administration of 50 μL CFA or 0.9% sterile saline in the right hind paw (Two-way repeated measures ANOVA followed by Tukey’s post-test for multiple comparisons, ***p < .001). (c): Plasma levels of corticosterone assessed by radioimmunoassay at 10 days after CFA or saline administration (Student t test, * p < .05). (d): Total distance travelled in the open field test at 10 days after CFA or saline administration (Student t test). N = 8/group. Results are expressed as mean ± the standard error of the mean (SEM). CFA, Complete Freund’s adjuvant.