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. 2022 Aug 8;12:922332. doi: 10.3389/fonc.2022.922332

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Copyright © 2022 Hu, Wang, Ma, Zhang and Xue

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Genomics and transcriptomics-based bioinformatic analysis on cuproptosis-related genes in lung adenocarcinoma. (A) CNV frequencies showed the loss and gain of ten cuproptosis biomarkers. (B) TMB of cuproptosis biomarkers and the proportion of base-pair alterations in LUAD samples. (For exmale, C>T: cytidine being replaced by adenosine, and so on in a similar fashion.) (C) ROC curves showed overall survival of single cuproptosis-related gene expression in LUAD patients. (D) Association between cuproptosis biomarkers expression and LUAD risks. (For example, DLD was up-regulated in LUAD samples; DLD expression was a risk factor for LUAD patients; and DLD expression was positively correlated with LIPT1, LIAS, FDX1, PDHB, PDHA1, and DLAT).