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. 2022 Aug 8;14:981868. doi: 10.3389/fnagi.2022.981868

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Copyright © 2022 Wood and Woltjer.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Relative levels of ether (PSe) serine GPL in the frontal cortex gray matter (GM) in controls (black bar), Mild Cognitive Impairment (MCI; red bars), early onset dementia (EOAD; blue bars) and late-onset dementia (LOAD; green bars). *p < 0.01; ^**p < 0.05. Relative levels are the ratio of the peak intensity of each serine lipid to that of the peak intensity of phosphatidylcholine 34:2 [phosphatidylcholine (PC) 34:2] multiplied by 100 to yield a percentage (Mean ± SEM). (B) Relative levels of ether (PSe) and vinyl-ether (PSp) serine GPL in the frontal cortex white matter (GM) in controls (black bar), Mild Cognitive Impairment (MCI; red bars), early onset dementia (EOAD; blue bars) and late-onset dementia (LOAD; green bars). *p < 0.01. Relative levels are the ratio of the peak intensity of each serine lipid to that of the peak intensity of phosphatidylcholine 34:2 (PC 34:2) multiplied by 100 to yield a percentage (Mean ± SEM).