FIG. 3.

Alignment of the putative NAD(H)-NADP(H) binding (A) and catalytic (B) sites of S. coelicolor Orf11 protein (Orf11_Strco) with those of other SDRs. Origins of the proteins and (in parentheses) their Swissprot database accession numbers are as follows: Dhb1_human, human (P14061); Fabg_Ecoli, E. coli (P25716); Enta_Ecoli, E. coli (P15047); 2bhd_Strex, Streptomyces exfoliatus (P19992); Ridh_Kleae, Klebsiella aerogenes (P00335); Phbb_Zoora, Zoogloea ramigera (P23238); Act3_Strco, S. coelicolor (P16544); and Dhkr_Strcm, Streptomyces cinnamonensis (P41177). Conserved and similar residues are in black and gray boxes, respectively (plurality, 5). The amino acids reported to play a role in either site are indicated.