Table 1 –
Demographic, biopsy and pathological data for the study cohort according to biopsy setting a
| External | External + review | Internal | p value | |
|---|---|---|---|---|
|
| ||||
| Patients, n (%) | 134 (16) | 313 (37) | 401 (47) | |
| Age (yr) | 65.1 (57.8–68.7) | 63.2 (57.6–68.3) | 66.4 (61.9–70.9) | <0.0001 |
| Preoperative PSA (ng/ml) | 7.1 (5.4–10.4) | 6.4 (4.7–9.0) | 6.9 (4.8–10.0) | 0.046 |
| Clinical stage | ||||
| cT1 | 76 (57) | 167 (53) | 255 (64) | |
| cT2 | 41 (30) | 110 (35) | 110 (27) | 0.077 |
| cT3 | 17 (13) | 36 (12) | 36 (9) | |
| D’Amico risk group | ||||
| Low | 30 (22) | 37 (12) | 21 (5) | |
| Intermediate | 76 (57) | 199 (64) | 257 (64) | <0.0001 |
| High | 28 (21) | 77 (24) | 123 (31) | |
| Biopsy Gleason score | ||||
| ≤6 | 48 (36) | 62 (20) | 37 (9) | |
| 7 | 75 (56) | 196 (63) | 265 (66) | <0.0001 |
| >7 | 11 (8) | 55 (17) | 99 (25) | |
| Biopsy ISUP grade | ||||
| 1 | 48 (36) | 62 (20) | 37 (9) | |
| 2 | 45 (34) | 128 (41) | 166 (41) | |
| 3 | 30 (22) | 69 (22) | 99 (25) | <0.0001 |
| 4 | 7 (5) | 33 (11) | 47 (12) | |
| 5 | 4 (3) | 21 (6) | 52 (13) | |
| Number of cores (n) | 12 (12–16) | 12 (12–16) | 14 (12–16) | <0.0001 |
| Positive cores (n) | 5 (2–8) | 5 (3–7) | 5 (3–7) | 0.086 |
| Positive core rate (%) | 35.7 (20.0–59.3) | 37.5 (21.1–53.8) | 36.4 (21.4–50.0) | 0.9 |
| Pathological ISUP grade | ||||
| 1 | 5 (4) | 10 (3) | 9 (2) | 0.034 |
| 2 | 51 (38) | 132 (42) | 151 (38) | |
| 3 | 52 (39) | 115 (37) | 125 (31) | |
| 4 | 7 (5) | 11 (4) | 35 (9) | |
| 5 | 19 (14) | 45 (14) | 81 (20) | |
| pT stage | ||||
| pT2 | 59 (44) | 153 (49) | 179 (44) | 0.5 |
| pT3a | 58 (43) | 127 (40) | 163 (41) | |
| pT3b | 17 (13) | 33 (11) | 59 (15) | |
| Extraprostatic extension | ||||
| No | 59 (44) | 153 (49) | 179 (45) | 0.5 |
| Yes | 75 (56) | 160 (51) | 222 (55) | |
| Seminal vesicle invasion | ||||
| No | 117 (87) | 280 (89) | 342 (85) | 0.3 |
| Yes | 17 (13) | 33 (11) | 59 (15) | |
| Perineural invasion | ||||
| No | 128 (96) | 302 (96) | 372 (93) | 0.082 |
| Yes | 6 (4) | 11 (4) | 29 (7) | |
| Positive surgical margins | ||||
| No | 84 (63) | 219 (70) | 294 (73) | 0.064 |
| Yes | 50 (37) | 94 (30) | 107 (27) | |
| pN stage | ||||
| pN0 | 101 (75) | 201 (64) | 269 (67) | 0.020 |
| pN1 | 16 (12) | 35 (11) | 60 (15) | |
| pNx | 17 (13) | 77 (25) | 72 (18) | |
| Pathological prostate weight (g) | 50 (38–62) | 52 (43–62) | 52 (43–65) | 0.07 |
| Pathological tumor volume (cm3) | 4.3 (2.0–7.9) | 5 (2.5–9.0) | 5.2 (2.9–10.0) | 0.02 |
PSA = prostate-specific antigen; ISUP = International Society of Urological Pathology.
a
Data are presented as median (interquartile range) for continuous variables and as n (%) for categorical variables.