Table 2.
Univariable analysis of prognostic factors.
| Local control | ||||
|---|---|---|---|---|
| Variable | Level | N (%) | Hazard Ratio (95%CI) | p Value |
| ECOG | 0 | 1 (1.5%) | 1.0 (ref) | |
| > 0 | 7 (11.3%) | 11.1 (10.3-111.9) | p = 0.016 | |
| Lung progression-free survival | ||||
| Variable | Level | N (%) | Hazard Ratio (95%CI) | p Value |
| Number of lung metastases | Single lung metastasis | 38 (42.2%) | 1.0 (ref) | |
| Multiple lung metastases | 19 (65.5%) | 3.9 (3.2-4.6) | p = 0.017 | |
| Oligoprogressive disease | Other | 39 (43.3%) | 1.0 (ref) | |
| Oligoprogressive disease | 18 (78.3%) | 11.9 (8.4-16.8) | p < 0.001 | |
| Oligometastatic state | Other | 20 (79.9%) | 1.0 (ref) | |
| Metachronous oligometastatic state | 37 (42.5%) | 0.10 (0.07-0.13) | p < 0.001 | |
| Progression-free survival | ||||
| Variable | Level | N (%) | Hazard Ratio (95%CI) | p Value |
| Number of lung metastases | Single lung metastase | 43 (51.2%) | 1.0 (ref) | |
| Multiple lung metastases | 21 (72.4%) | 3.9 (3.2-4.7) | p < 0.01 | |
| Oligoprogressive disease | Other | 45 (50.0%) | 1.0 (ref) | |
| Oligoprogressive disease | 19 (82.6%) | 10.5 (7.0-15.6) | p < 0.001 | |
| Oligometastatic state | Other | 21 (80.8%) | 1.0 (ref) | |
| Metachronous oligometastatic state | 43 (49.4%) | 0.11 (0.08-0.16) | p < 0.001 | |
| Overall survival | ||||
| Variable | Level | N (%) | Hazard Ratio (95%CI) | p Value |
| ECOG | 0 | 12 (25.0%) | 1.0 (ref) | |
| > 0 | 28 (50.9%) | 3.5 (3.2-3.8) | p < 0.01 | |
| Radiation pneumonitis | ||||
| Variable | Level | N (%) | Hazard Ratio (95%CI) | p Value |
| Age | < 65 years | 13 (28.3%) | 1.0 (ref) | |
| > 65 years | 52 (64.2%) | 3.6 (3.2-4.0) | p < 0.001 | |
| V10Gy | < 351 cc | 21 (42.0%) | 1.0 (ref) | |
| > 351 cc | 30 (66.7%) | 4.7 (4.1-5.4) | p = 0.022 | |
| V35Gy | < 32.9 cc | 18 (36.0%) | 1.0 (ref) | |
| > 32.9 cc | 33 (71.7%) | 5.1 (4.4-5.9) | p < 0.01 | |