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. 2022 Aug 22;10(16):e15439. doi: 10.14814/phy2.15439

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© 2022 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Role of adipocyte IRF4 in metabolic inflammation and blood glucose control. (a) AdipoIRF4^fl/fl model validation by quantification of transcript levels of Irf4 in whole white adipose tissue (left) and liver (right) of WT^fl/fl and AdipoIRF4^fl/fl mice. (b) Immune cell IRF4 is positioned as a sex‐independent mediator of the anti‐inflammatory actions of MDP during low‐dose endotoxin and HFD‐induced obesity. However, lower adipose tissue inflammation is not always sufficient to promote improved blood glucose control. Adipocyte IRF4 mediates the glucose‐lowering effects of MDP during low‐dose endotoxin and HFD‐induced obesity in a sex‐dependent manner, but it is unknown how sex‐dependent factors influence adipocyte IRF4 and the glucose response to MDP.