Table 3.
Area under the receiver operating characteristic for predicting 28-day mortality in the original, modified, and vasopressor only cardiovascular/total SOFA
| Original model | Modified model | Vasopressor only model | pa | pb | |
|---|---|---|---|---|---|
| AUROC (95% CI) of cardiovascular SOFA | |||||
| Derivation cohort |
0.624 (0.596–0.652) |
0.682 (0.654–0.709) |
0.625 (0.597–0.653) |
< 0.001 | 0.125 |
| Internal validation |
0.638 (0.596–0.680) |
0.716 (0.678–0.754) |
0.640 (0.598–0.683) |
< 0.001 | 0.023 |
| External validation 1 |
0.557 (0.536–0.579) |
0.648 (0.627–0.669) |
0.610 (0.587–0.632) |
< 0.001 | < 0.001 |
| External validation 2 |
0.589 (0.565–0.612) |
0.674 (0.650–0.700) |
0.635 (0.610–0.660) |
< 0.001 | < 0.001 |
| AUROC (95% CI) of total SOFA | |||||
| Derivation cohort |
0.750 (0.725–0.776) |
0.762 (0.738–0.787) |
0.751 (0.725–0.776) |
< 0.001 | 0.682 |
| Internal validation |
0.773 (0.736–0.810) |
0.787 (0.751–0.822) |
0.774 (0.738–0.811) |
0.001 | 0.495 |
| External validation 1 |
0.678 (0.658–0.699) |
0.712 (0.693–0.732) |
0.704 (0.684–0.724) |
< 0.001 | < 0.001 |
| External validation 2 |
0.712 (0.688–0.735) |
0.736 (0.714–0.758) |
0.726 (0.703–0.749) |
< 0.001 | < 0.001 |
SOFA Sequential organ failure assessment, AUROC Area under the receiver operating characteristic
aOriginal vs. modified model
bOriginal vs. vasopressor only model