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. 2022 Aug 22;14:95. doi: 10.1186/s13073-022-01076-0

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Genotype and resistance category distribution of strains across 1852 clinical isolates (Total) and within the three major clusters. A Distribution of resistance category across the 1852 isolates; resistance categories are RR (rifampicin resistant), nonMDR (resistant, but not multi drug resistant [MDR]), MDR, pre-XDR (pre-extensively drug resistant), and XDR (extensively drug resistant); of the total strain population, about 37% are susceptible (S) to all drugs, 38% of strains are pre-XDR whereas 2.4% are XDR in the cohort. The resistant category distribution of clusters 1, 2, and 3 differs, with all strains being at least MDR). B Proportion of strains with known resistance mutations per lineage. Each bar represents a specific antibiotic or compensatory effect. L2 strains, especially the ones from clusters 1–3, have the highest proportion of resistance mutations and also compensatory effects. Abbreviations: INH, isoniazid; RMP, rifampicin; Comp., compensatory mutation; EMB, ethambutol; PZA, pyrazinamide; MFX, moxifloxacin; Inj., injectables; PTH, prothionamide; PAS, para-aminosalycilic acid; CS, cycloserine; BDQ, bedaquiline; CFZ, clofazimine; LZD, linezolid; L1, Lineage 1; L2, Lineage 2; L3, Lineage 3; L4, Lineage 4