Table 1.
Characteristics of MDR and pre-XDR/XDR cases with factors associated with pre-XDR/XDR-TB based on univariate and multivariate analysis
| MDR | Pre-XDR/XDR | Univariate analysis | Multivariate logistic regression | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n | % | n | % | OR | 95% lower | 95% upper | P-value | Adjusted OR | 95% lower | 95% upper | Adjusted P-value | |
| Total | 268 | 100% | 748 | 100% | ||||||||
| Gender | ||||||||||||
| M | 114 | 43% | 320 | 43% | 1.00 | 0.75 | 1.35 | 1 | ||||
| F | 153 | 57% | 428 | 57% | ||||||||
| Unknown | 1 | 0% | 0 | 0% | ||||||||
| Age | ||||||||||||
| < 18 | 37 | 14% | 93 | 12% | 0.89 | 0.58 | 1.38 | 0.59 | ||||
| 18–40 | 168 | 63% | 489 | 65% | 1.12 | 0.83 | 1.52 | 0.46 | ||||
| 40–60 | 45 | 17% | 138 | 18% | 1.12 | 0.77 | 1.66 | 0.58 | ||||
| > 60 | 17 | 6% | 29 | 4% | 0.6 | 0.31 | 1.18 | 0.12 | ||||
| Unknown | 1 | 0% | 0 | 0% | ||||||||
| Lineage | ||||||||||||
| Lineage 1 (EAI) | 37 | 14% | 13 | 2% | 0.11 | 0.05 | 0.22 | < 0.001 | 0.19 | 0.09 | 0.41 | < 0.001 |
| Lineage 2 (Beijing) | 121 | 45% | 592 | 79% | 4.60 | 3.38 | 6.28 | < 0.001 | 2.09 | 1.26 | 3.45 | < 0.01 |
| Lineage 3 (Delhi-CAS) | 70 | 26% | 69 | 9% | 0.29 | 0.20 | 0.42 | < 0.001 | 0.54 | 0.32 | 0.89 | 0.02 |
| Lineage 4 (Euro-American) | 40 | 15% | 74 | 10% | 0.63 | 0.41 | 0.97 | 0.03 | ||||
| M. bovis | 0 | 0% | 0 | 0% | ||||||||
| Clustering | ||||||||||||
| Yes | 155 | 58% | 591 | 79% | 2.74 | 2.01 | 3.74 | < 0.001 | 0.92 | 0.62 | 1.35 | 0.66 |
| No | 113 | 42% | 157 | 21% | ||||||||
| Cluster | ||||||||||||
| Cluster 1 | 44 | 16% | 213 | 28% | 2.03 | 1.40 | 2.98 | < 0.001 | 1.19 | 0.74 | 1.91 | 0.46 |
| Cluster 2 | 12 | 4% | 115 | 15% | 3.87 | 2.09 | 7.85 | < 0.001 | 2.36 | 1.19 | 4.69 | 0.01 |
| Cluster 3 | 16 | 6% | 71 | 9% | 1.65 | 0.93 | 3.10 | 0.09 | 1.09 | 0.58 | 2.08 | 0.79 |