Table 3.
Sensitivity analysis regarding the risk of IBS according to Quartiles of baseline fatty liver index
| FLI Quartiles | No. of IBS | No. of participants | Adjusted HR (95%CI) | P value | P for trend |
|---|---|---|---|---|---|
| Sensitivity analysis 1: excluding IBS participants diagnosed within 1 year after baseline (N = 396,184) | |||||
| Quartile 1 | 1691 | 98,180 | Reference | < 0.001 | |
| Quartile 2 | 1659 | 99,151 | 1.15 (1.08–1.24) | < 0.001 | |
| Quartile 3 | 1552 | 99,565 | 1.19 (1.11–1.28) | < 0.001 | |
| Quartile 4 | 1573 | 99,288 | 1.21 (1.12–1.31) | < 0.001 | |
| Sensitivity analysis 2: excluding IBS participants diagnosed within 2 years after baseline (N = 395,546) | |||||
| Quartile 1 | 1509 | 97,998 | Reference | ||
| Quartile 2 | 1495 | 98,987 | 1.16 (1.08–1.25) | < 0.001 | < 0.001 |
| Quartile 3 | 1405 | 99,418 | 1.20 (1.11–1.30) | < 0.001 | |
| Quartile 4 | 1428 | 99,143 | 1.22 (1.13–1.32) | < 0.001 | |
| Sensitivity analysis 3: excluding incident alcoholic liver disease participants after baseline (N = 395,775) | |||||
| Quartile 1 | 1878 | 98,306 | Reference | ||
| Quartile 2 | 1793 | 99,161 | 1.12 (1.05–1.20) | 0.001 | < 0.001 |
| Quartile 3 | 1696 | 99,496 | 1.18 (1.10–1.26) | < 0.001 | |
| Quartile 4 | 1737 | 98,812 | 1.21 (1.13–1.30) | < 0.001 | |
| Sensitivity analysis 4: competing risk model (N = 396,838, No. of competing events = 24,742) | |||||
| Quartile 1 | 1882 | 98,371 | Reference | ||
| Quartile 2 | 1797 | 99,289 | 1.13 (1.05–1.20) | 0.001 | < 0.001 |
| Quartile 3 | 1701 | 99,714 | 1.18 (1.10–1.26) | < 0.001 | |
| Quartile 4 | 1749 | 99,464 | 1.21 (1.12–1.30) | < 0.001 | |
| Sensitivity analysis 5: excluding HBV or HCV antigen-positive participants after baseline (N = 396,613) | |||||
| Quartile 1 | 1877 | 98,310 | Reference | ||
| Quartile 2 | 1796 | 99,235 | 1.13 (1.05, 1.20) | < 0.001 | < 0.001 |
| Quartile 3 | 1701 | 99,665 | 1.18 (1.10, 1.26) | < 0.001 | |
| Quartile 4 | 1749 | 99,403 | 1.21 (1.13, 1.30) | < 0.001 | |
| Sensitivity analysis 6: additionally adjusted psychologic disorder including depression and anxiety (N = 396,838) | |||||
| Quartile 1 | 1882 | 98,371 | Reference | ||
| Quartile 2 | 1797 | 99,289 | 1.11 (1.03–1.18) | 0.003 | < 0.001 |
| Quartile 3 | 1701 | 99,714 | 1.14 (1.07–1.23) | < 0.001 | |
| Quartile 4 | 1749 | 99,464 | 1.16 (1.08–1.24) | < 0.001 | |
Note: All adjusted HRs were calculated by adjusting the following covariates: age, gender, Townsend deprivation index, education level, ethnicity, smoking status, alcohol drinking, IPAQ (International Physical Activity Questionnaire) and type 2 diabetes. P for trend was calculated by using the median value of each fatty liver index Quartile (10.5, 32.2, 61.2, and 88.6 for sensitivity analysis 1, 2, 4, 5, and 6; 10.5, 32.2, 61.2, and 88.5 for sensitivity analysis 3)
IBS irritable bowel syndrome, HR hazard ratio, CI confidence interval