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. 2022 Aug 22;23:176. doi: 10.1186/s13059-022-02745-4

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Data summary and conservation of transcriptomes of 20 common tissues in humans and cattle. a Sample size per tissue in humans and cattle. b Spearman’s correlation of number of expressed genes (median TPM > 0.1) across tissues between humans and cattle. Each dot represents a tissue. c Plot of t-SNE of samples based on batch-corrected gene expression (Methods). Each dot represents a sample, colored by species types. d Same as in c, but colored by tissue types. e Percentage of orthologous genes shared in each window between humans and cattle. Genes were ranked (from largest to smallest) by median expression in each tissue each species, and then divided into ten windows evenly (1731 genes per window)