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. Author manuscript; available in PMC: 2022 Sep 7.
Published in final edited form as: Nat Med. 2022 Mar 7;28(3):468–471. doi: 10.1038/s41591-022-01708-3

Extended Data Fig. 9. Murine mutational signatures similar to human mutational signatures associated with smoking and defective DNA repair:

Extended Data Fig. 9

A: De novo murine mutational signatures (Msig1 and Msig2) were created from high and moderate impact snps and show greater signature activities in the WTC-PM exposed mice.

B: The murine signatures were compared to known human mutational signatures. Greater similarity was shown with higher intensity of color on the heatmap. Human signatures with most similarity to Msig1 were SBS45, SBS4, SBS94. Human signatures with most similarity to Msig2 were SBS5, SBS3, SBS40.

C: Human signatures with most similarity to murine signatures were SBS 03, 04, 05, 40, 45 and 90.