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(A) Inhibition of selected human ectonucleotidases by ceritinib (50 µM). (B) and (C) Concentration-dependent inhibition of NTPDase3 (B)and NTPDase8 (C) by ceritinib determined by the malachite green assay applying an ATP substrate concentration of 100 µM. For calculated IC50 values see table 1. NPP, nucleotide pyrophosphatase/phosphodiesterase; NTPDase, nucleoside triphosphate diphosphohydrolase.
