Fig. 2.

Effects of formyl peptide receptor 1 (FPR1) pharmacologic modulation in colorectal carcinoma (CRC) cells on angiogenic response. (A) VEGF‐A, VEGF‐B, VEGF‐C, VEGF‐D, Ang1 and CXCL1 mRNA fold change in HT29 and HCT116 cells treated with fMLF (10⁻⁹  m) or CsH (800 nm) for 3 h. Data are represented as mean ± SD of five independent experiments. *P < 0.05 compared with the control (dotted line) by Student's t test. (B) VEGF‐A release in HCT116 cells treated with fMLF (10⁻⁹  m) or CsH (800 nm) or the relative controls for 12 h. Data are represented as mean ± SD of five independent experiments. *P < 0.05 compared with the control by Student's t test. (C) Correlation between the mRNA expression levels of the indicated markers in 594 patients affected by colorectal adenocarcinoma. Spearman's factor, Pearson's factor and the relative p are indicated. [Colour figure can be viewed at wileyonlinelibrary.com]