Table 1.

Clinical and biological characteristics of 80 patients with HPV positive head and neck squamous cell carcinoma, and association with overall survival. OS, overall survival; NS, non‐significant; CT, chemotherapy; RT, radiotherapy.

Heading	Patients (%)	Events (%)	OS (P‐value) h
Total	80 (100)	26 (32.5)
Age (years)
<65	45 (56.2)	10 (22.2)
≥65	35 (43.8)	16 (45.7)	0.02
Gender
Male	60 (75)	21 (35)
Female	20 (25)	5 (25)	0.44 (NS)
Tobacco a
Yes	48 (60.8)	18 (37.5)
No	31 (39.2)	7 (22.6)	0.32 (NS)
Alcohol b
Yes	19 (25)	7 (36.8)
No	57 (75)	18 (31.6)	0.7 (NS)
Localization
Oropharynx	73 (91.2)	22 (30.1)	0.12 (NS)
Non‐oropharyngeal	7 (8.8)	4 (57.1)
Tumour stage c
I	20 (26.7)	4 (20)	0.002
II	32 (42.7)	7 (21.9)
III	22 (29.3)	12 (54.5)
IV	1 (1.3)	1 (100)
Lymph node invasion c
Yes	64 (85.3)	21 (32.8)	0.68 (NS)
No	11 (14.7)	3 (27.3)
HPV genotype
Genotype 16	72 (90)	22 (30.5)	0.16 (NS)
Other genotypes	8 (10)	4 (50)
Tumour differentiation d
Well/moderate	32 (56.1)	14 (43.8)	0.36 (NS)
Poor	25 (43.9)	8 (32)
Mitotic index e
Low/moderate	8 (20)	3 (37.5)	0.93 (NS)
High	32 (80)	11 (34.4)
Perineural invasion f
Yes	12 (28.6)	4 (33.3)	0.97 (NS)
No	30 (71.4)	8 (26.7)
Lymphovascular invasion g
Yes	17 (37)	6 (35.3)	0.80 (NS)
No	29 (63)	10 (34.5)
Initial therapy a
Surgery with or without induction CT	8 (10.1)	1 (12.5)	0.55 (NS)
Exclusive (chemo)RT	15 (19)	5 (33.3)
Surgery followed by (chemo)radiation	54 (68.4)	19 (35.2)
None	2 (2.5)	1 (50)

^a Data available for 79 patients.

^b Data available for 76 patients.

^c Data available for 75 patients.

^d Data available for 57 patients

^e Data available for 40.

^f Data available for 42.

^g Data available for 46.

^h Univariate analysis (Kaplan–Meier method).