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. 2022 Jul 22;12(8):674. doi: 10.3390/metabo12080674

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Stratified analysis of associations of nasopharyngeal and serum glutathione-related metabolites with severity outcome in infants hospitalized for bronchiolitis, by respiratory syncytial virus infection. (A). Multivariable-adjusted association of nasopharyngeal glutathione-related metabolites with PPV use in infants with RSV infection. The ORs were estimated for a 1% change in the relative abundance of metabolites. (B). Multivariable-adjusted association of nasopharyngeal glutathione-related metabolites with PPV use without RSV infection. The ORs were estimated for a 1% change in the relative abundance of metabolites. (C). Multivariable-adjusted association of serum glutathione-related metabolites with PPV use with RSV infection. The ORs were estimated in a 2-fold change in the abundance of metabolites. (D). Multivariable-adjusted association of serum glutathione-related metabolites with PPV use without RSV infection. The ORs were estimated in a 2-fold change in the abundance of metabolites. Arrows indicate that the 95%CI of the odds ratio exceeds the lower or higher limit of the x-axis. * Estimated by fitting logistic regression model adjusting for potential confounders (age and sex). † The Benjamini–Hochberg FDR method was used to account for multiple testing. Abbreviations: CI, confidence interval; FDR, false discovery rate; OR, odds ratio; PPV, positive pressure ventilation; RSV, respiratory syncytial virus.