Figure 6.
Association of glutathione-related metabolite signatures with risk of developing asthma. The nasopharyngeal and serum glutathione-related metabolite signatures for PPV use were estimated by constructing generalized additive models. Then, the association of the signature with the risk of developing asthma was estimated by fitting logistic regression models. The ORs were estimated in a change in the weighted sum of the glutathione-related metabolite coefficients. * Estimated by fitting logistic regression model adjusting for potential confounders (age, sex, race/ethnicity, prematurity, daycare use, cigarette smoke exposure at home, maternal smoking during pregnancy, parent history of eczema, RSV infection, RV infection, and any IgE sensitization). Abbreviations: CI, confidence interval; IgE, Immunoglobulin E; OR, odds ratio; PPV, positive pressure ventilation; RSV, respiratory syncytial virus; RV, rhinovirus.