Table 1.

RyR2 domain distribution of disease-linked mutations.

Domain	Coordinates (Amino Acids)	Length (Amino Acids)	Number of Mutations	Mutation Frequency Overall (%)	Mutation Frequency within Domain (%)
NTD	1–640	640	58	16.9	9.1
SPRY1	641–850	209	7	2.0	3.3
RY1&2	876–1066	190	9	2.6	4.7
SPRY2	1087–1254	167	5	1.5	3.0
SPRY3	1255–1603	348	14	4.1	4.0
JSol	1641–2105	464	16	4.7	3.4
BSolB	2109–2678	569	68	19.8	11.9
RY3&4	2714–2904	190	7	2.0	3.7
BSolC	2976–3527	551	11	3.2	2.0
CSol	3612–4206	594	74	21.6	12.5
Unresolved	4207–4483	276	5	1.5	1.8
TMD	4484–4886	402	55	16.0	13.7
CTD	4887–4967	80	14	4.1	17.5