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The effect of the CB1 and CB2 receptor antagonists on the synergism induced by the combination of IBU (39.54 mg/kg, s.c.) and WIN (2.74 µg/p, i.pl.). Statistical significance is indicated between the COMB group and groups receiving the individual antagonists or their combination (**** p < 0.0001). Data are expressed as the mean ± SEM of six repetitions.
