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. 2022 Mar 8;12(3):670–691. doi: 10.1158/2159-8290.CD-21-0683

Figure 6.

Figure 6. Comprehensive single-cell atlas of gastric cancer. This study included more than 200,000 cells from 31 primary gastric tumor samples. In total, 34 distinct cell-lineage states were identified, related by developmental trajectories and previously unreported rare cell populations. An increase in plasma cell proportions was observed as a feature of diffuse-type tumors associated with epithelial-resident KLF2. A stage-wise accrual of novel cancer-associated fibroblast subpopulations was marked by high INHBA and FAP coexpression. Findings were complemented using digital spatial transcriptomics and RNAScope. Our results provide a high-resolution molecular resource for gastric cancer translational studies, identifying intra- and interpatient lineage states across distinct gastric cancer subtypes.

Comprehensive single-cell atlas of gastric cancer. This study included more than 200,000 cells from 31 primary gastric tumor samples. In total, 34 distinct cell-lineage states were identified, related by developmental trajectories and previously unreported rare cell populations. An increase in plasma cell proportions was observed as a feature of diffuse-type tumors associated with epithelial-resident KLF2. A stage-wise accrual of novel cancer-associated fibroblast subpopulations was marked by high INHBA and FAP coexpression. Findings were complemented using digital spatial transcriptomics and RNAScope. Our results provide a high-resolution molecular resource for gastric cancer translational studies, identifying intra- and interpatient lineage states across distinct gastric cancer subtypes.