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. 2022 Mar 8;12(3):692–711. doi: 10.1158/2159-8290.CD-21-0669

Figure 4.

Figure 4. Mutational signature analysis of GIS-NENs. Hierarchical clustering by de novo extraction of mutational signatures with nonnegative matrix factorization of available WGS data. Stability plotting indicated 12 mutational signatures (>0.85; Supplementary Fig. S18). Their profiles and functions were assigned based on COSMIC SBS Signatures (v3.1). Sto, stomach; Eso, esophagus, Col, colorectum; Pan, pancreas; Amp, ampullary; Bil, bile duct; Platinum, platinum chemotherapy treatment; Merkel, gastric NEC with Merkel cell polyomavirus. The parentheses in the left figure indicate cosine similarity to COSMIC signatures.

Mutational signature analysis of GIS-NENs. Hierarchical clustering by de novo extraction of mutational signatures with nonnegative matrix factorization of available WGS data. Stability plotting indicated 12 mutational signatures (>0.85; Supplementary Fig. S18). Their profiles and functions were assigned based on COSMIC SBS Signatures (v3.1). Sto, stomach; Eso, esophagus, Col, colorectum; Pan, pancreas; Amp, ampullary; Bil, bile duct; Platinum, platinum chemotherapy treatment; Merkel, gastric NEC with Merkel cell polyomavirus. The parentheses in the left figure indicate cosine similarity to COSMIC signatures.