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. 2022 Jul 22;11(8):1426. doi: 10.3390/antiox11081426

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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NRF2-signalling-based therapeutic strategies in brain dysfunctions. Targeting NRF2 pathway in brain diseases appears as a promising therapeutic strategy. Different options exist depending on the context (cancer (A), ageing (B), and neurodegenerative diseases (C)), NRF2 levels, and the cells to target (neuronal or glial cells). NRF2 and NRF2-negative regulators (KEAP1, BACH1, BACH2) can be targeted in these different conditions. The emergence of senotherapeutic drugs (senolytics, senomorphics) coupled to epigenetic modifiers (inhibitors/activators of histone acetyltransferases, histone deacetylases, histone demethylases, and histone methyltransferases) could provide a great number of translational opportunities and thus contribute to improving human health.

NRF2-signalling-based therapeutic strategies in brain dysfunctions. Targeting NRF2 pathway in brain diseases appears as a promising therapeutic strategy. Different options exist depending on the context (cancer (A), ageing (B), and neurodegenerative diseases (C)), NRF2 levels, and the cells to target (neuronal or glial cells). NRF2 and NRF2-negative regulators (KEAP1, BACH1, BACH2) can be targeted in these different conditions. The emergence of senotherapeutic drugs (senolytics, senomorphics) coupled to epigenetic modifiers (inhibitors/activators of histone acetyltransferases, histone deacetylases, histone demethylases, and histone methyltransferases) could provide a great number of translational opportunities and thus contribute to improving human health.