Table 4:
Greatest Absolute Increase in Exposure Between 2010 and 2018
| Rank | Medication | Exposure Increasea | Exposure in 2010a | Exposure in 2018a | FDA Label for Use |
|---|---|---|---|---|---|
| 1 | Poractant alfa | 45.0 | 63.4 | 108.4 | Yes |
| 2 | Morphine | 19.7 | 53.7 | 73.4 | No |
| 3 | Erythromycin | 9.8 | 24.1 | 33.9 | Yes |
| 4 | Glucose gel | 8.8 | 0.0 | 8.8 | No |
| 5 | Simethicone | 8.4 | 7.5 | 15.9 | No |
| 6 | Budesonide | 6.8 | 7.5 | 14.3 | No |
| 7 | Clonidine | 6.3 | 0.4 | 6.7 | No |
| 8 | Acetaminophen | 5.3 | 40.9 | 46.2 | Yes |
| 9 | Dexmedetomidine | 5.0 | 0.1 | 5.1 | No |
| 10 | Fluconazole | 4.7 | 20.8 | 25.5 | No |
| 11 | Levetiracetam | 4.7 | 1.7 | 6.4 | No |
| 12 | Hydrocortisone | 4.5 | 21.6 | 26.1 | No |
| 13 | Cefepime | 4.1 | 7.9 | 12.0 | No |
| 14 | Cefazolin | 2.9 | 8.4 | 11.3 | No |
| 15 | Cholestyramine | 1.9 | 3.4 | 5.3 | No |
| 16 | Atropine | 1.7 | 0.9 | 2.6 | No |
| 17 | Rocuronium | 1.4 | 0.2 | 1.6 | No |
| 18 | Penicillin G | 1.3 | 4.7 | 6.0 | No |
| 19 | Ceftriaxone | 1.2 | 1.3 | 2.5 | Yes |
| 20 | Dexamethasone | 1.1 | 15.7 | 16.8 | No |
a
Per 1000 infants
FDA = Federal Drug Administration