Table 6:
Greatest Relative Increase in Exposure Between 2010 and 2018
| Rank | Medication | % Change | Exposure (2010)a | Exposure (2018)a | FDA Label for Use |
|---|---|---|---|---|---|
| 1 | Dexmedetomidine | 5000 | 0.1 | 5.1 | No |
| 2 | Clonidine | 1575 | 0.4 | 6.7 | No |
| 3 | Rocuronium | 700 | 0.2 | 1.6 | No |
| 4 | Levetiracetam | 276 | 1.7 | 6.4 | No |
| 5 | Atropine | 189 | 0.9 | 2.6 | No |
| 6 | Diazoxide | 150 | 0.6 | 1.5 | Yes |
| 7 | Vasopressin/Desmopressin | 140 | 0.5 | 1.2 | No |
| 8 | Glycopyrrolate | 120 | 0.5 | 1.1 | No |
| 9 | Simethicone | 112 | 7.5 | 15.9 | No |
| 10 | Glucagon | 100 | 0.5 | 1.0 | No |
| 11 | Ceftriaxone | 92 | 1.3 | 2.5 | Yes |
| 12 | Budesonide | 91 | 7.5 | 14.3 | No |
| 13 | Sucralfate | 71 | 1.4 | 2.4 | No |
| 14 | Poractant alfa | 71 | 63.4 | 108.4 | Yes |
| 15 | Ampicillin-sulbactam | 57 | 0.7 | 1.1 | No |
| 16 | Cholestyramine | 56 | 3.4 | 5.3 | No |
| 17 | Cefepime | 52 | 7.9 | 12.0 | No |
| 18 | Ganciclovir | 43 | 0.7 | 1.0 | No |
| 19 | Erythromycin | 41 | 24.1 | 33.9 | Yes |
| 20 | Magnesium sulfate | 38 | 0.8 | 1.1 | No |
a
Per 1,000 infants
FDA = Federal Drug Administration