Table 1.
Characteristics of GAS surveillance population and PTE
|
Surveillance population characteristics | |||||
|---|---|---|---|---|---|
|
Disease* |
Total (%) |
Adult (%) |
Paediatric (%) |
emm† |
|
|
INV |
221 (17) |
52 (23.5) |
169 (76.5) |
1, 12, 89, 6, 4 |
|
|
SSTI |
180 (14) |
47 (26.1) |
133 (73.9) |
1, 12, 4, 89, 92 |
|
|
PHG |
889 (69) |
72 (8.1) |
817 (91.9) |
1, 12, 89, 28, 6 |
|
|
Total |
1290 |
171 (13.3) |
1119 (86.7) |
1, 12, 89, 28, 6 |
|
|
Potential transmission events | |||||
|
PTE‡ |
Age (years)§ |
Days|| |
Disease¶ |
emm |
SNPs** |
|
17 |
2/65 |
7 |
INV/INV |
1 |
1 |
|
20 |
6/3 |
29 |
INV/PHG |
12 |
3 |
|
28 |
16/7 |
5 |
PHG/SSTI |
1 |
14 |
|
36 |
3/33 |
18 |
PHG/SSTI |
1 |
10 |
|
42 |
5/8 |
1 |
INV/PHG |
1 |
0 |
|
45†† |
6/6 |
8 |
PHG/PHG |
1 |
13 |
*Disease category as defined in text.
†Most common emm types in order of frequency for given disease type.
‡Potential transmission event (single index to PTE) as defined in Table S1.
§Age of index/transmission subjects in years.
||Number of days between index case diagnosis and PTE.
¶Disease type for index/transmission.
**Number of SNPs in core genome differentiating PTE from index isolate.
††WGS evidence for transmission between PTE-1 and PTE-2 of a four-strain cluster as shown in Table S1.
INV, invasive; PHG, pharyngeal; PTE, potential transmission event; SNP, single nucleotide polymorphism; SSTI, skin and soft tissue infection.