Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Aug 8;15:965756. doi: 10.3389/fnmol.2022.965756

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Blagburn-Blanco, Chappell, De Biase and DeNardo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Region-, synapse-, and age-specific roles for microglia in synapse refinement. (A) Microglia prune retinogeniculate synapses at P9 using a C4-dependent pathway (Yilmaz et al., 2021). (B) Overexpression of C4 enhances synapse pruning in mPFC (Yilmaz et al., 2021). (C) At P15, microglia prune axosomatic synapses between basket cells and pyramidal cells (Favuzzi et al., 2021) while promoting the formation of axo-axonic synapses between chandelier cells and pyramidal cells (Gallo et al., 2022) in rodent somatosensory cortex. (D) Neuronal Fn14 together with microglial TWEAK refine dLGN dendritic spines through activity-dependent, non-phagocytic mechanisms (Cheadle et al., 2020). (E) Synaptogenesis and refinement overlap in space and time and occur over distinct windows of development in sensory systems vs. prefrontal cortex.