Table 3. Demographic and clinical features affecting progression among multiple sclerosis patients.

		Total	Time taken to reach EDSS 4			Time taken to reach EDSS 6			Time taken to go from EDSS 4 to EDSS 6
			Median	95%Cl	p-value	Median	95%Cl	p-value	Median	95%Cl	p-value
General		741	15.4	12.9-17.9		21.9	18.8-25.0		3.0	2.5-3.5
Sex
	Female	486	15.4	12.9-17.9	0.370	20.2	15.8-24.6	0.595	3.0	2.4-3.7	0.713
	Male	255	14.2	8.6-19.9		23.5	15.8-31.1		2.8	1.9-3.7
Age at onset
	<18	59	17.8	8.2-27.5	<0.001*	25.9		0.003*	5.6	0-11.9	0.110
	18-40	560	16.3	12.9-19.7		20.2	16.3-24.1		2.8	2.0-3.5
	>40	122	10.3	8.7-11.8		15.6	10.5-20.6		3.3	2.6-3.9
Disease onset
	Monosymptomatic	661	15.8	13.3-18.4	0.002*	23.5	19.0-27.9	0.001*	3.0	2.4-3.7	0.285
	Polysymptomatic	80	9.1	7.0-11.2		13.0	10.9-15.1		2.9	1.7-4.0
First attack type
	Visual	173	19.7	17.8-21.6	<0.001*	24.3	21.2-27.4	<0.001*	3.0	1.5-4.6	0.013*
	Brainstem-cerebellar	176	13.5	7.9-19.2		23.1	13.4-32.8		2.2	1.3-3.1
	Pyramidal	232	10.2	8.3-12.0		16.4	13-19.8		3.4	2.4-4.4
	Sensory	151	42.2
	Bladder-intestinal	9	8.2	0-18.5		10.3	2.7-17.8		2.0	1.8-2.2
Number of attacks in 5 years
	1-3	519	19.7	16.6-22.9	<0.001*	28.7	23.9-33.5	<0.001*	5.3	3.2-7.3	0.001*
	4-6	174	10.8	8.2-13.4		15.9	12.4-19.5		2.8	2.5-3.1
	≥7	48	5.9	1.2-10.7		11.4	9.1-13.6		3.2	1.8-2.5
Time between first two attacks
	<2 years	428	11.3	9.3-13.2	<0.001*	16.5	12.9-20.1	<0.001*	2.9	2.3-3.5	0.453
	2-5 years	197	17.1	11.9-22.3		20.2	18.4-22.0		3.0	1.0-5.3
	>5 years	107	20.7	16.8-24.7		28.7	25.4-32.0		3.5	1.0-6.1
Time of treatment after diagnosis
	≤2 years	320	14.2	6.2-22.2	0.210			0.753	5.0	2.9-7.0	0.015*
	>2 years	340	15.4	12.7-18.1		21.1	17.7-24.5		2.7	2.2-3.2
Smoking
	Yes	191	14.2	7.4-21.0	0.846	21.1	13.5-28.7	0.243	2.6	1.8-3.3	0.018*
	No	347	15.5	12.8-18.2		20.1	15.2-28.5		4.2	2.3-6.1
Number of cigarettes per day
	1-10	50	19.0	3.1-34.9	0.583			0.200	2.7	1.0-4.8	0.470
	≥10	97	15.8	8.4-23.3		21.1			2.8	0-5.6

EDSS: Expanded Disability Status Scale; 95%CI: 95% confidence interval.