Table 3.
Antimicrobial Susceptibility Changes and the Characteristics of Resistant Phenotypes of Different KPC Mutant Types of CZA Resistant Strains
| Carbapenemases | Isolate | Interpretive Categories | ESBL | AMPc | Efflux Pump | |||
|---|---|---|---|---|---|---|---|---|
| IMP | MEM | TGC | CZA | |||||
| KPC-2 | LY0B1 | R | R | S | S | – | – | – |
| KPC-33/86/88 | LYOF1 HMOF1 207F |
S/I | S/I | S | R | + | – | – |
| KPC-44/87 | LYOF2 LYOF2Y LYOF3Y |
R | R | S | R | – | – | – |
Abbreviations: IMP, imipenem; MEM, meropenem; TGC, tigecycline; CZA, ceftazidime/avibactam; MLST, Multiple-locus sequence typing; ESBL, extended-spectrum beta-lactamase; AmpC, AmpC beta lactamase.