Table 4.

Association between TyG, triglycerides and fasting glucose to 4-point MACE in patients with CKD (n = 1142)

	Unadjusted MACE 4-pt		Model 1a		Model 2b		Model 3c
	HR (95% CI)	P	HR (95% CI)	P	HR (95% CI)	P	HR (95% CI)	P
TyG (per unit increase)	1.95 (1.11–3.40)	0.018	2.14 (1.18–3.90)	0.012	2.01 (1.09–3.70)	0.025	1.94 (1.01–3.73)	0.046
TyG ≥ 8.63 (median value)	2.29 (1.24–4.20)	0.008	2.22 (1.21–4.09)	0.010	2.09 (1.13–3.88)	0.019	2.54 (1.27–5.07)	0.008
Glucose (per mg/dL)	1.02 (1.00–1.05)	0.048	1.02 (0.99–1.04)	0.246	1.01 (0.99–1.04)	0.308	1.01 (0.98–1.03)	0.608
Triglycerides (per mg/dL)	1.00 (1.00–1.00)	0.099	1.00 (1.00–1.01)	0.021	1.00 (1.00–1.01)	0.040	1.00 (0.99–1.01)	0.143

The association of each parameter [TyG (per unit increase), TyG (≥8.63), glucose and triglycerides] to 4-point MACE is assessed separately in three different adjusted models.

TyG: triglycerides–glucose index; HR: hazard ratio; 95% CI: 95% confidence interval. TyG = Ln (TG [mg/dL] × glucose [mg/dL]/2).

^aModel 1: Cox regression adjusted for age and gender.

^bModel 2: Cox regression adjusted for age, sex, hypertension and dyslipidemia.

^cModel 3. Cox regression adjusted for age, sex, hypertension and atherosclerotic score.