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. 2022 Aug 22;17(8):e0272920. doi: 10.1371/journal.pone.0272920

Table 1. Summary of meta-analysis results for the prevalence of occult hepatitis B in blood donors.

Prevalence. % (95%CI) 95% Prediction interval N Studies N Participants H (95%CI) §I2 (95%CI) P heterogeneity
Occult hepatitis B virus prevalence in HBsAg negative & anti-HBc positive blood donors
Overall 6.6 [5.7–7.5] [2.2–12.8] 53 6756446 10.9 [10.5–11.5] 99.2 [99.1–99.2] <0.001
Cross-sectional 6.6 [5.7–7.5] [2.2–12.8] 53 6756446 10.9 [10.5–11.5] 99.2 [99.1–99.2] <0.001
Low risk of bias 9.9 [7.7–12.3] [1.1–25.2] 30 6503856 12.6 [11.9–13.3] 99.4 [99.3–99.4] <0.001
Occult hepatitis B virus prevalence in HBsAg negative & anti-HBc negative blood donors
Overall 0 [0–0] [0–0.2] 7 72555 1.4 [1–2.1] 46.7 [0–77.5] 0.081
Cross-sectional 0 [0–0] [0–0.2] 7 72555 1.4 [1–2.1] 46.7 [0–77.5] 0.081
Low risk of bias 0 [0–0] [0–0] 4 72107 1 [1–2.6] 0 [0–84.7] 0.731
Occult hepatitis B virus prevalence in HBsAg negative blood donors
Overall 0.3 [0.2–0.4] [0–1] 27 567324 5.8 [5.2–6.4] 97 [96.3–97.5] <0.001
Cross-sectional 0.2 [0.1–0.3] [0–0.9] 26 566816 5.7 [5.1–6.3] 96.9 [96.2–97.5] <0.001
Low risk of bias 0.4 [0.2–0.5] [0–1.2] 15 467345 6.7 [5.9–7.5] 97.7 [97.1–98.2] <0.001

CI: confidence interval; N: Number; 95% CI: 95% Confidence Interval; NA: not applicable.

H is a measure of the extent of heterogeneity, a value of H = 1 indicates homogeneity of effects and a value of H >1indicates a potential heterogeneity of effects.

§: I2 describes the proportion of total variation in study estimates that is due to heterogeneity, a value > 50% indicates presence of heterogeneity