Table 1. Summary of meta-analysis results for the prevalence of occult hepatitis B in blood donors.
Prevalence. % (95%CI) | 95% Prediction interval | N Studies | N Participants | ¶H (95%CI) | §I2 (95%CI) | P heterogeneity | |
---|---|---|---|---|---|---|---|
Occult hepatitis B virus prevalence in HBsAg negative & anti-HBc positive blood donors | |||||||
Overall | 6.6 [5.7–7.5] | [2.2–12.8] | 53 | 6756446 | 10.9 [10.5–11.5] | 99.2 [99.1–99.2] | <0.001 |
Cross-sectional | 6.6 [5.7–7.5] | [2.2–12.8] | 53 | 6756446 | 10.9 [10.5–11.5] | 99.2 [99.1–99.2] | <0.001 |
Low risk of bias | 9.9 [7.7–12.3] | [1.1–25.2] | 30 | 6503856 | 12.6 [11.9–13.3] | 99.4 [99.3–99.4] | <0.001 |
Occult hepatitis B virus prevalence in HBsAg negative & anti-HBc negative blood donors | |||||||
Overall | 0 [0–0] | [0–0.2] | 7 | 72555 | 1.4 [1–2.1] | 46.7 [0–77.5] | 0.081 |
Cross-sectional | 0 [0–0] | [0–0.2] | 7 | 72555 | 1.4 [1–2.1] | 46.7 [0–77.5] | 0.081 |
Low risk of bias | 0 [0–0] | [0–0] | 4 | 72107 | 1 [1–2.6] | 0 [0–84.7] | 0.731 |
Occult hepatitis B virus prevalence in HBsAg negative blood donors | |||||||
Overall | 0.3 [0.2–0.4] | [0–1] | 27 | 567324 | 5.8 [5.2–6.4] | 97 [96.3–97.5] | <0.001 |
Cross-sectional | 0.2 [0.1–0.3] | [0–0.9] | 26 | 566816 | 5.7 [5.1–6.3] | 96.9 [96.2–97.5] | <0.001 |
Low risk of bias | 0.4 [0.2–0.5] | [0–1.2] | 15 | 467345 | 6.7 [5.9–7.5] | 97.7 [97.1–98.2] | <0.001 |
CI: confidence interval; N: Number; 95% CI: 95% Confidence Interval; NA: not applicable.
¶H is a measure of the extent of heterogeneity, a value of H = 1 indicates homogeneity of effects and a value of H >1indicates a potential heterogeneity of effects.
§: I2 describes the proportion of total variation in study estimates that is due to heterogeneity, a value > 50% indicates presence of heterogeneity