Table 4 Multivariate analyses of prognostic factors correlated with PFS and OS.

Characteristics	PFS		OS
	HR (95%CI)	P value	HR (95%CI)	P value
HHLA2 expression (Low vs high)	0.268 (0.126 to 0.571)	0.001	0.334 (0.147 to 0.755)	0.008
ECOG PS (0 vs 1-2)	3.041 (1.467 to 6.304)	0.003	3.353 (1.527 to 7.361)	0.003
Liver metastasis (no vs yes)	2.368 (1.261 to 4.447)	0.007	2.847 (1.483 to 5.465)	0.002

*P values <0.05 in bold are statistically significant.

HHLA2, human endogenous retrovirus-H long terminal repeat-associating protein 2; ECOG PS, Eastern Cooperative Oncology Group Performance Status.