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. 2022 Aug 8;13:957771. doi: 10.3389/fphar.2022.957771

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Copyright © 2022 Lv, Liu, Sun, Wang, Zhang and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Bioeffects of stem cells derived exosomes on wound healing. (A) EdSC can inhibit inflammation by regulating the number of inflammatory cells and the polarization of macrophages. (B) EdSC can promote re-epithelialization by increasing the activity of fibroblasts as well as keratinocytes and activating pathways. (C) EdSC can improve angiogenesis by stimulating the release of angiogenic factors and regulating the activity of endothelial cells. (D) EdSC can improve tissue remodeling by regulating the ratio of collagen and myofibroblast differentiation.