Table 4:

Correlations between changes in patient and care partner items (ESAS-PD, patient FACIT-Sp-12, care partner FACIT-Sp-12, patient HADS, care partner HADS, and patient PG-12) and overall scores for patient QOL (QOL-AD) at 6 months, caregiver burden (ZBI) at 12 months, patient global impression of improvement at 12 months, and care partner global impression of change at 12 months.

Item Change Scores	Patient QOL (QOL-AD) Change Score (6 months)	Caregiver Burden (ZBI) Change Score (12 months)	Patient Global impression of improvement Change Score (12 months)	Care partner Global impression of improvement Change Score (12 months)
	ρ	ρ	ρ	ρ
Pain	0.02	0.04	−0.18	−0.19
Tiredness	−0.16	0.05	−0.14	−0.05
Nausea	−0.15	0.13	−0.02	−0.06
Depression	−0.18	0.11	−0.19	−0.03
Anxiety	−0.24	0.25	−0.20	−0.20
Drowsiness	−0.18	0.12	−0.13	0.00
Appetite	−0.03	0.13	−0.18	−0.16
Wellbeing	−0.43	0.02	−0.34	−0.26
Shortness of Breath	−0.24	0.04	−0.06	0.14
Other	−0.41	0.28	−0.39
Stiffness	−0.27	0.10	−0.16	−0.05
Constipation	−0.12	0.15	0.08	0.06
Dysphagia	−0.09	0.08	−0.07	0.04
Confusion	−0.27	0.10	−0.12	−0.19
Amotivation	−0.10	0.16	−0.27	−0.24
Hallucinations	−0.23	0.09	−0.04	0.06
ESAS Total (12 point)	−0.39	0.22	−0.30	−0.22
ESAS-Total (14 point)	−0.39	0.22	−0.29	−0.21
Patient FACIT-Sp	0.40	−0.07	0.26	0.16
Care partner FACIT-Sp	−0.10	−0.27	0.12	0.13
Patient HADS-Anxiety	−0.40	0.22	−0.39	−0.34
Patient HADS-depression	−0.56	0.00	−0.36	−0.33
Care partner HADS-Anxiety	−0.12	0.43	−0.02	0.00
Care partner HADS-Depression	0.05	0.41	−0.12	−0.19
PG-12	−0.46	0.11	−0.40	−0.23
Completion of advance directives	0.06	0.13	−0.14	−0.13

ρ =Spearman correlation coefficients

Light gradation=p<0.05

Dark gradation=p<0.0001