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. 2022 Jun 3;46(9):1624–1632. doi: 10.1038/s41366-022-01157-5

Table 3.

Two-by-two table of prediction models’ validity at selected cut-off.

“Optimum Data Availability” Cut-off: 0.217 “Scottish Data” Cut-off: 0.226
N = 2118 True (observed) outcome N = 2279 True (observed) outcome
Obese Non-obese TOTALS Obese Non-obese TOTALS
Predicted outcome Obese 297 387 784 Obese 314 388 702
Non-obese 92 1342 1434 Non-obese 98 1479 1577
TOTALS 389 (Obese) 1729 (Non-Obese) TOTALS 412 (Obese) 1867 (Non-Obese)
Sensitivity: 297/389 = 76.3% Sensitivity: 314/412= 76.2%
Specificity: 1342/1729 = 77.6% Specificity: 1479/1867= 79.2%
PPV 297/784= 37.8% PPV: 314/702= 44.7%
NPV 1342/1434= 93.6% NPV: 1479/1577= 93.8%
Referral Burden: 784/2118 = 37.0% Referral Burden: 702/2279 = 30.8%

Of the 387 “false positives” from the Optimal data model 160 (41.4%) were overweight, so that those unlikely to benefit at all would be 227 or 10.7% of all those screened; of the 388 “false positives” from Scottish data model 161 (41.5%) were overweight, so that those unlikely to benefit at all would be 227 or 10.0% of all those screened.

PPV positive predictive value, NPV negative predictive value.